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I need to create an web application using python and deploy it on a local server so that any system connected locally to that server can use that app.

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I would strongly look at using something like Django inside of a docker container e.g. the standard python container.

This combination should have minimum security risks and allow easy portability & scaling.

There is a nice walk through of using Docker Compose to run a simple Django/PostgreSQL app here.

You may find it worth looking at Gunicorn - have a look at Dockerizing Django with Postgres, Gunicorn, and Nginx.

There are a number of Python web frameworks available but Django is one of the more popular so lots of support and advice is available.

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