You should not expect any Python runtime in Wbassembly production-grade stable yet. Webassembly came out 2 years ago. Pyodide (supported by Mozilla) is the most well supported Python AFAIK.
BTW, have you actually tried Pyodide? It runs quite well in my computer.
There is now a library that does much of this (for Rust)!
Expose a full suite of Web APIs as exposed by web browsers.
Be a ...
ccall(ident, returnType, argTypes, args, opts)
Call a compiled C function from ...