Overall process of load testing tools selection is highlighted in Open Source Load Testing Tools: Which One Should You Use?.
Well-behaved load test should mimic real users using real browsers so from the application under test point of view it should be no difference so consider simulating:
Handling embedded resources (images, fonts, scripts, styles, etc) in the way browsers do
Don't forget about Cache because browsers fetch these resources only once (or according to Cache-...
If you're planning to load test the web interface - both tools will fit as both support HTTP protocol including recording.
With regards to the choice:
On one hand LoadRunner is a proprietary load testing tool so you might get benefit from their support
On the other hand LoadRunner is paid tool, 50 virtual users you get for free, the next ones ...