I'm working on an interactive animation project in HTML5. Currently I'm using Adobe animate cc, but animate cc does not support 3D animation in HTML5 document. I'm looking to switch to some other software which support high quality animation (2D & 3D both) and interactivity. Which are the softwares that support interactive animation (2D & 3D)? It could be both paid, open source and other then HTML5.
You can try Blender for 3D modelling, animation and texturing, and one of its multiple addons for exporting to the web.
Blender can do 2D animation with Grease Pencil feature, though I don't think it can be exported, and can othwerwise simulate 2D animation with 3D elements exportable to the web