Like most internet denizens, I am also a big fan of XKCD, Oatmeal and websites like Learn you a Haskell which use humorous cartoons for expressing interesting ideas. What softwares do these guys use for creating such cartoonish (but complex) images?
Are there any open source softwares for this? I am famiilar with Inkscape of course, but I use these for general technical diagrams. For cartoonish diagrams which look as if they are hand-drawn, I don't know if Inkscape can recreate it (without a lot of pain and modulating the splines )
Also I am quite good at drawing cartoons with my hand on paper, but when it comes to doing the same with say Inkscape, my mouse does not allow me to perform fine touches. Are there special computer mice which graphic illustrators use for creating their content?