On Chrome, there is an extension called Downloads Router. Looking for something similar for Firefox. The Downloads Router allows you to automatically save your downloads to different folders based on a rule set. For example, I can create a rule to save all files download from www.xyz.com to ~/Downloads/xyz folder.
This is the only thing preventing me from dumping the Chrome browser. :)
You can safely dump Chrome... allow me to introduce you to Firefox's Save In... extension.
The summary on AMO is well written:
Adds a context menu to save media {image, video, audio, link, selection, page} in user-defined directories relative to the default download location. Save into dynamically named directories. Rules-based download renaming and routing. [emphasis mine]
Voila!
And if you would also like to read a whole article written about the extension, here is a nice one.
