Most people uses RStudio, at least on Windows, but it has a problem, it connects to R using TCP, through 127.0.0.1 port 8787.
That causes problems in many computers, related with the antivirus, the firewall and performamnce issues.
Sometimes they can be solved modifying the settings of the computer, but that's not always possible.
I think other GUI use the same approach.
Is there any other alternative? With R embedded in the program itself or with other kind of communication between executables.