WinPython is a portable python toolkit that also allows you to add packages to it while keeping it portable. It can run either from a USB key or from a directory on the hard drive but without actual installation, (copying is not quite the same as installation).
Then you have a wide range of python based blog generators, there is a list of some of them here, but personally I would take a look at ABlog.
As a test I downloaded the 64 bit version of winpython 184.108.40.206 and installed it to my hard drive the install took up <1.4 GB without ABlog and installing took seconds and didn't make a noticeable difference to the size as most of the dependencies were already met. N.B. For the most portability I would suggest using the 32 bit version rather than the 64 bit.
ABlog is a Sphinx extension that converts any documentation or personal website project into a full-fledged blog with:
- Atom feeds
- Archive pages
- Blog sidebars
- Disqus integration
- Font-Awesome integration
- Easy GitHub Pages deploys
I did hit a couple of hickups following the tutorial due to non-ascii characters on line 22 of the generated conf.py but since that was a comment deleting it solved the issue.
My First Blog page with ABlog:
Of course you will now have a full portable version of python & iPython to play with and a suite of scientific tools, graphing, etc. to play with in them!