Pickle is a sprite editing application targeting pixel artists creating video games.
- It supports mirrored drawing, rotate/flip and live preview of your tiles in arbitrary configurations.
- Previous versions were free but at 2.0, it is now paid software (currently US$25).
- It is built using Adobe Air and has downloads available for Windows and Mac.
Pyxel Edit is a sprite editing application targeting the game development community.
- It supports live previewing with tile instances in arbitrary configurations, these instances can be flipped or rotated if desired.
- An older version is available for free, with the current version being paid software (currently US$9+).
- It is also built using Adobe Air, with downloads available for Windows and Mac.
My personal experiences are that the Pickle interface is streamlined and easier to quickly come to grips with. However it lacks some handy features that Pyxel Edit supports including layers, import/export pallet images, and auto-generated gradients. I have no experience using either application for animation, something they both have a lot of features devoted to.